HIF1AN anticorps (AA 2-254)
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- Antigène Voir toutes HIF1AN Anticorps
- HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))
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Épitope
- AA 2-254
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HIF1AN est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- Réactivité croisée
- Humain, Souris
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human Hypoxia-inducible factor 1-alpha inhibitor protein (2-254AA)
- Isotype
- IgG
- Top Product
- Discover our top product HIF1AN Anticorps primaire
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- Indications d'application
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200, IP:1:200-1:2000,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))
- Autre désignation
- HIF1AN (HIF1AN Produits)
- Synonymes
- anticorps FIH1, anticorps 2310046M24Rik, anticorps A830014H24Rik, anticorps cb728, anticorps id:ibd5139, anticorps hypoxia inducible factor 1 alpha subunit inhibitor, anticorps hypoxia-inducible factor 1, alpha subunit inhibitor, anticorps hypoxia inducible factor 1, alpha subunit inhibitor, anticorps hypoxia-inducible factor 1, alpha subunit inhibitor S homeolog, anticorps HIF1AN, anticorps Hif1an, anticorps hif1an, anticorps hif1an.S
- Sujet
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Background: Hydroxylates HIF-1 alpha at \\\'Asp-803\\\' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Aliases: DKFZp762F1811 antibody, Factor inhibiting HIF-1 antibody, Factor inhibiting HIF1 antibody, FIH 1 antibody, FIH-1 antibody, FIH1 antibody, FLJ20615 antibody, FLJ22027 antibody, HIF1AN antibody, HIF1N_HUMAN antibody, Hypoxia inducible factor 1 alpha inhibitor antibody, Hypoxia inducible factor 1 alpha subunit inhibitor antibody, Hypoxia inducible factor asparagine hydroxylase antibody, Hypoxia-inducible factor 1-alpha inhibitor antibody, Hypoxia-inducible factor asparagine hydroxylase antibody, Peptide aspartate beta dioxygenase antibody
- UniProt
- Q9NWT6
- Pathways
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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