IPO13 anticorps (AA 501-700) (Biotin)

N° du produit ABIN7156143

Détail du produit anti-IPO13 anticorps (Biotin)

Antigène: IPO13 (Importin 13 (IPO13))

Épitope: AA 501-700

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IPO13 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Importin-13 protein (501-700AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur IPO13

Antigène: IPO13 (Importin 13 (IPO13))

Autre désignation: IPO13 (IPO13 Produits)

Synonymes: anticorps 3R23, anticorps CG 7212, anticorps CG7212, anticorps Dmel\\CG7212, anticorps Imp13, anticorps imp13, anticorps sd-5, anticorps DDBDRAFT_0205767, anticorps DDBDRAFT_0304414, anticorps DDB_0205767, anticorps DDB_0304414, anticorps DDBDRAFT_0191787, anticorps DDBDRAFT_0304413, anticorps DDB_0191787, anticorps DDB_0304413, anticorps IMP13, anticorps KAP13, anticorps LGL2, anticorps RANBP13, anticorps Kap13, anticorps Ranbp13, anticorps Lgl2, anticorps DKFZp459H088, anticorps cadmus, anticorps importin 13, anticorps cdm, anticorps IPO13, anticorps AFUA_5G08060, anticorps ANI_1_1340034, anticorps AOR_1_1272114, anticorps ipo13B, anticorps ipo13A, anticorps ipo13, anticorps Ipo13

Sujet:

Background: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.

Aliases: Imp 13 antibody, Imp13 antibody, Importin-13 antibody, Importin13 antibody, IPO 13 antibody, Ipo13 antibody, IPO13_HUMAN antibody, Kap 13 antibody, Kap13 antibody, Karyopherin 13 antibody, Karyopherin-13 antibody, Karyopherin13 antibody, KIAA0274 antibody, Late gestation lung 2 antibody, Late gestation lung 2 protein antibody, Lgl2 antibody, Ran binding protein 13 antibody, Ran-binding protein 13 antibody, RanBP 13 antibody, RanBP13 antibody

UniProt: O94829

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Protein targeting to Nucleus