Integrin beta 7 anticorps (AA 1-140)

N° du produit ABIN7156498

Détail du produit anti-Integrin beta 7 anticorps

Antigène: Integrin beta 7 (ITGB7)

Épitope: AA 1-140

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Integrin beta 7 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Integrin beta-7 protein (1-140AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Integrin beta 7

Antigène: Integrin beta 7 (ITGB7)

Autre désignation: ITGB7 (ITGB7 Produits)

Synonymes: anticorps Ly69, anticorps integrin beta 7, anticorps integrin subunit beta 7, anticorps integrin, beta 7, anticorps Itgb7, anticorps ITGB7

Sujet:

Background: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Aliases: Gut homing receptor beta subunit antibody, Integrin beta 7 subunit antibody, Integrin beta-7 antibody, Integrin beta-P antibody, Integrin, beta 7 antibody, ITB7 antibody, ITB7_HUMAN antibody, Itgb7 antibody, Ly69 antibody, M290 IEL antigen antibody

UniProt: P26010

Pathways: Integrin Complex