IFIH1 anticorps (AA 700-1025)

N° du produit ABIN7156651

Détail du produit anti-IFIH1 anticorps

Antigène: IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))

Épitope: AA 700-1025

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFIH1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Interferon-induced helicase C domain-containing protein 1 protein (700-1025AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur IFIH1

Antigène: IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))

Autre désignation: IFIH1 (IFIH1 Produits)

Synonymes: anticorps MDA5, anticorps Hlcd, anticorps IDDM19, anticorps MDA-5, anticorps RLR-2, anticorps 9130009C22Rik, anticorps Helicard, anticorps RGD1560496, anticorps interferon induced with helicase C domain 1, anticorps IFIH1, anticorps Ifih1

Sujet:

Background: Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2\'-O-methylation at their 5\' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs), IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.

Aliases: CADM-140 autoantigen antibody, Clinically amyopathic dermatomyositis autoantigen 140 kDa antibody, DEAD/H (Asp Glu Ala Asp/His) box polypeptide antibody, DEAD/H box polypeptide antibody, Helicard antibody, Helicase with 2 CARD domains antibody, Hlcd antibody, IDDM 19 antibody, IDDM19 antibody, IFIH 1 antibody, Ifih1 antibody, IFIH1_HUMAN antibody, Interferon induced helicase C domain containing protein 1 antibody, interferon induced with helicase C domain 1 antibody, Interferon induced with helicase C domain protein 1 antibody, Interferon-induced helicase C domain-containing protein 1 antibody, Interferon-induced with helicase C domain protein 1 antibody, MDA 5 antibody, MDA-5 antibody, Melanoma differentiation associated protein 5 antibody, Melanoma differentiation-associated gene 5 antibody, Melanoma differentiation-associated protein 5 antibody, MGC133047 antibody, Murabutide down regulated protein antibody, Murabutide down-regulated protein antibody, RH 116 antibody, RH116 antibody, RIG I like receptor 2 antibody, RLR 2 antibody, RNA helicase DEAD box protein 116 antibody, RNA helicase-DEAD box protein 116 antibody

UniProt: Q9BYX4

Pathways: Activation of Innate immune Response