IFIT3 anticorps (AA 1-490) (Biotin)

N° du produit ABIN7156672

Détail du produit anti-IFIT3 anticorps (Biotin)

Antigène: IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))

Épitope: AA 1-490

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFIT3 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Interferon-induced protein with tetratricopeptide repeats 3 protein (1-490AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur IFIT3

Antigène: IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))

Autre désignation: IFIT3 (IFIT3 Produits)

Synonymes: anticorps DKFZp469G2233, anticorps CIG-49, anticorps GARG-49, anticorps IFI60, anticorps IFIT4, anticorps IRG2, anticorps ISG60, anticorps P60, anticorps RIG-G, anticorps Ifi49, anticorps P49, anticorps IFIT-3, anticorps interferon induced protein with tetratricopeptide repeats 3, anticorps interferon-induced protein with tetratricopeptide repeats 3, anticorps IFIT3, anticorps Ifit3

Sujet:

Background: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.

Aliases: CIG 49 antibody, CIG49 antibody, GARG 49 antibody, IFI-60K antibody, IFI60 antibody, IFI60K antibody, IFIT-3 antibody, IFIT-4 antibody, Ifit3 antibody, IFIT3_HUMAN antibody, IFIT4 antibody, Interferon induced 60 kDa protein antibody, Interferon induced protein 60 antibody, Interferon induced protein with tetratricopeptide repeats 3 antibody, Interferon-induced 60 kDa protein antibody, Interferon-induced protein with tetratricopeptide repeats 3 antibody, Interferon-induced protein with tetratricopeptide repeats 4 antibody, IRG2 antibody, ISG-60 antibody, ISG60 antibody, P60 antibody, Retinoic acid induced gene G protein antibody, Retinoic acid-induced gene G protein antibody, RIG G antibody, RIG-G antibody, RIGG antibody, RP11-149I23.4 antibody

UniProt: O14879