JMY anticorps (AA 708-848)
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- Antigène Voir toutes JMY Anticorps
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
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Épitope
- AA 708-848
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp JMY est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human Junction-mediating and -regulatory protein (708-848AA)
- Isotype
- IgG
- Top Product
- Discover our top product JMY Anticorps primaire
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- Indications d'application
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
- Autre désignation
- JMY (JMY Produits)
- Synonymes
- anticorps WHDC1L3, anticorps junction mediating and regulatory protein, p53 cofactor, anticorps junction-mediating and regulatory protein, anticorps JMY, anticorps jmy, anticorps Jmy
- Sujet
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Background: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).
Aliases: FLJ37870 antibody, Jmy antibody, JMY protein antibody, JMY_HUMAN antibody, junction mediating and regulatory protein antibody, Junction mediating and regulatory protein p53 cofactor antibody, Junction-mediating and -regulatory protein antibody, MGC163496 antibody, OTTHUMP00000161976 antibody, WAS protein homology region 2 domain containing 1-like 3 antibody, WHDC1L3 antibody
- UniProt
- Q8N9B5
- Pathways
- Regulation of Actin Filament Polymerization
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