LAIR1 anticorps (AA 22-165)

N° du produit ABIN7158291

Détail du produit anti-LAIR1 anticorps

Antigène: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Épitope: AA 22-165

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LAIR1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Leukocyte-associated immunoglobulin-like receptor 1 protein (22-165AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur LAIR1

Antigène: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Autre désignation: LAIR1 (LAIR1 Produits)

Synonymes: anticorps 5133400O11Rik, anticorps BB115266, anticorps D7Bwg0421e, anticorps Lair-1, anticorps mLair-1, anticorps CD305, anticorps LAIR-1, anticorps leukocyte-associated Ig-like receptor 1, anticorps leukocyte associated immunoglobulin like receptor 1, anticorps leukocyte-associated immunoglobulin-like receptor 1, anticorps Lair1, anticorps LAIR1

Sujet:

Background: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

Aliases: 5133400O11Rik antibody, CD305 antibody, D7Bwg0421e antibody, hLAIR1 antibody, LAIR 1 antibody, LAIR-1 antibody, LAIR1 antibody, LAIR1 protein antibody, LAIR1_HUMAN antibody, Leukocyte associated Ig like receptor 1 antibody, Leukocyte associated immunoglobulin like receptor 1 antibody, Leukocyte-associated immunoglobulin-like receptor 1 antibody

UniProt: Q6GTX8