LRP6 anticorps (AA 20-150)

N° du produit ABIN7158577

Détail du produit anti-LRP6 anticorps

Antigène: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Épitope: AA 20-150

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRP6 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Low-density lipoprotein receptor-related protein 6 protein (20-150AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur LRP6

Antigène: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Autre désignation: LRP6 (LRP6 Produits)

Synonymes: anticorps lrp6-A, anticorps Xlrp6, anticorps adcad2, anticorps lrp6, anticorps LRP6, anticorps ADCAD2, anticorps C030016K15Rik, anticorps Cd, anticorps Gw, anticorps LDL receptor related protein 6, anticorps LDL receptor related protein 6 L homeolog, anticorps LDL receptor related protein 6 S homeolog, anticorps low density lipoprotein receptor-related protein 6, anticorps low-density lipoprotein receptor-related protein 6, anticorps LRP6, anticorps lrp6.L, anticorps lrp6.S, anticorps lrp6, anticorps Lrp6, anticorps LOC590395

Sujet:

Background: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

Aliases: ADCAD2 antibody, C030016K15Rik antibody, Cd antibody, FLJ90062 antibody, FLJ90421 antibody, LDL receptor related protein 6 antibody, Low density lipoprotein receptor related protein 6 antibody, Low-density lipoprotein receptor-related protein 6 antibody, LRP-6 antibody, LRP6 antibody, LRP6_HUMAN antibody, OTTHUMP00000238979 antibody, OTTHUMP00000238980 antibody, OTTHUMP00000238982 antibody, STHAG7 antibody

UniProt: O75581

Pathways: Signalisation WNT, Tube Formation