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LEF1 anticorps (AA 75-216)

LEF1 Reactivité: Humain WB, ELISA, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7158656
  • Antigène Voir toutes LEF1 Anticorps
    LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))
    Épitope
    • 10
    • 9
    • 7
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 75-216
    Reactivité
    • 78
    • 19
    • 13
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 49
    • 24
    • 4
    • 1
    Lapin
    Clonalité
    • 53
    • 25
    Polyclonal
    Conjugué
    • 58
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LEF1 est non-conjugé
    Application
    • 64
    • 34
    • 11
    • 8
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
     Réactivité croisée
    Humain, Souris
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Lymphoid enhancer-binding factor 1 protein (75-216AA)
    Isotype
    IgG
    Top Product
    Discover our top product LEF1 Anticorps primaire
  • Indications d'application
    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))
    Autre désignation
    LEF1 (LEF1 Produits)
    Synonymes
    anticorps LEF1, anticorps 3000002B05, anticorps AI451430, anticorps Lef-1, anticorps LEF-1, anticorps TCF10, anticorps TCF1ALPHA, anticorps TCF7L3, anticorps lymphoid enhancer binding factor 1, anticorps lymphoid enhancer-binding factor 1, anticorps lymphoid enhancer factor XLEF-1B, anticorps LEF1, anticorps lef1, anticorps Lef1
    Sujet

    Background: Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

    Aliases: DKFZp586H0919 antibody, FLJ46390 antibody, LEF 1 antibody, LEF-1 antibody, Lef1 antibody, LEF1_HUMAN antibody, Lymphoid enhancer binding factor 1 antibody, Lymphoid enhancer-binding factor 1 antibody, T cell specific transcription factor 1 alpha antibody, T cell-specific transcription factor 1-alpha antibody, TCF 1 alpha antibody, TCF1 alpha antibody, TCF1-alpha antibody, TCF10 antibody, TCF1alpha antibody, TCF7L3 antibody, Transcription factor T cell specific 1 alpha antibody

    UniProt
    Q9UJU2
    Pathways
    Signalisation WNT, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding
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