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BRCC3 anticorps (AA 14-316)

BRCC3 Reactivité: Humain WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7158679
  • Antigène Voir toutes BRCC3 Anticorps
    BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
    Épitope
    • 15
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 14-316
    Reactivité
    • 55
    • 16
    • 15
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 49
    • 6
    Lapin
    Clonalité
    • 51
    • 4
    Polyclonal
    Conjugué
    • 26
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BRCC3 est non-conjugé
    Application
    • 41
    • 18
    • 13
    • 13
    • 11
    • 9
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Lys-63-specific deubiquitinase BRCC36 protein (14-316AA)
    Isotype
    IgG
  • Indications d'application
    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
    Autre désignation
    BRCC3 (BRCC3 Produits)
    Synonymes
    anticorps CXorf53, anticorps BRCC3, anticorps xtp1, anticorps brcc3, anticorps BRCC36, anticorps brcc36, anticorps C6.1A, anticorps BRCA1/BRCA2-containing complex subunit 3, anticorps DEP domain containing 1B, anticorps BRCA1/BRCA2-containing complex, subunit 3, anticorps BRCA1/BRCA2-containing complex subunit 3 L homeolog, anticorps BRCC3, anticorps depdc1b, anticorps brcc3, anticorps Brcc3, anticorps brcc3.L
    Sujet

    Background: Metalloprotease that specifically cleaves \\\'Lys-63\\\'-linked polyubiquitin chains. Does not have activity toward \\\'Lys-48\\\'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes \\\'Lys-63\\\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes \\\'Lys-63\\\'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves \\\'Lys-63\\\'-linked ubiquitin in various substrates. Mediates the specific \\\'Lys-63\\\'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.

    Aliases: BRCA1-A complex subunit BRCC36 antibody, BRCA1/BRCA2 containing complex subunit 3 antibody, BRCA1/BRCA2 containing complex subunit 36 antibody, BRCA1/BRCA2-containing complex subunit 3 antibody, BRCA1/BRCA2-containing complex subunit 36 antibody, Brcc3 antibody, BRCC3_HUMAN antibody, BRCC36 antibody, BRISC complex subunit BRCC36 antibody, C6.1A antibody, Chromosome X open reading frame 53 antibody, CXorf53 antibody, Lys-63-specific deubiquitinase BRCC36 antibody, OTTHUMP00000061450 antibody

    UniProt
    P46736
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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