LSD1 anticorps (AA 100-150)

N° du produit ABIN7158724

Détail du produit anti-LSD1 anticorps

Antigène: LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

Épitope: AA 100-150

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LSD1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Lysine-specific histone demethylase 1A protein (100-150AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur LSD1

Antigène: LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

Autre désignation: KDM1A (KDM1A Produits)

Synonymes: anticorps AOF2, anticorps BHC110, anticorps KDM1, anticorps LSD1, anticorps 1810043O07Rik, anticorps AA408884, anticorps Aof2, anticorps D4Ertd478e, anticorps Kdm1, anticorps Lsd1, anticorps mKIAA0601, anticorps DKFZp459N2450, anticorps RGD1562975, anticorps aof2, anticorps kdm1, anticorps wu:fb82e06, anticorps wu:fc51a02, anticorps wu:fj36a05, anticorps wu:fj66b06, anticorps KDM1A, anticorps lsd1, anticorps xLSD1, anticorps AtLSD1, anticorps F9F13.30, anticorps F9F13_30, anticorps LESION SIMULATING DISEASE, anticorps LESION SIMULATING DISEASE 1, anticorps lysine demethylase 1A, anticorps lysine (K)-specific demethylase 1A, anticorps lysine (K)-specific demethylase 1a, anticorps LSD1 zinc finger family protein, anticorps KDM1A, anticorps Kdm1a, anticorps kdm1a, anticorps LSD1

Sujet:

Background: Histone demethylase that demethylates both \\\'Lys-4\\\' (H3K4me) and \\\'Lys-9\\\' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of \\\'Thr-6\\\' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated \\\'Lys-370\\\' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.

Aliases: Amine oxidase (flavin containing) domain 2 antibody, Amine oxidase, flavin containing, 2 antibody, AOF2 antibody, BHC110 antibody, BRAF35 HDAC complex protein BHC110 antibody, BRAF35-HDAC complex protein BHC110 antibody, BRAF35/HDAC complex, 110-kD subunit antibody, CPRF antibody, EC1 antibody, FAD binding protein BRAF35 HDAC complex, 110 kDa subunit antibody, Flavin-containing amine oxidase domain-containing protein 2 antibody, KDM 1 antibody, KDM1 antibody, Kdm1a antibody, KDM1A_HUMAN antibody, KIAA0601 antibody, LSD 1 antibody, LSD1 antibody, Lysine (K) specific demethylase 1 antibody, Lysine (K) specific demethylase 1A antibody, Lysine demethylase 1A antibody, Lysine specific histone demethylase 1 antibody, Lysine specific histone demethylase 1A antibody, Lysine-specific demethylase 1 antibody, Lysine-specific demethylase 1A antibody, Lysine-specific histone demethylase 1A antibody

UniProt: O60341

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, L'effet Warburg