LPAR1 anticorps (AA 316-364)

N° du produit ABIN7158744

Détail du produit anti-LPAR1 anticorps

Antigène: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Épitope: AA 316-364

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LPAR1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Lysophosphatidic acid receptor 1 protein (316-364AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur LPAR1

Antigène: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Autre désignation: LPAR1 (LPAR1 Produits)

Synonymes: anticorps EDG2, anticorps GPR26, anticorps Gpcr26, anticorps LPA1, anticorps Mrec1.3, anticorps VZG1, anticorps edg-2, anticorps rec.1.3, anticorps vzg-1, anticorps Edg2, anticorps EDG-2, anticorps 5031439C20, anticorps AI326300, anticorps Kdt2, anticorps lpA1, anticorps edg2, anticorps si:dz22b13.1, anticorps si:dz46m7.1, anticorps zgc:92157, anticorps LPA receptor 1-A, anticorps LPA-1-A, anticorps gpr26, anticorps lpa1, anticorps lpa1r, anticorps lpa1r1, anticorps lpar1, anticorps lpar1-a, anticorps lpar1-b, anticorps vzg1, anticorps xLPA1-1, anticorps LPA receptor 1-B, anticorps LPA-1-B, anticorps edg2-A, anticorps xLPA1-2, anticorps xlpa1R, anticorps lysophosphatidic acid receptor 1, anticorps lysophosphatidic acid receptor 1 S homeolog, anticorps lysophosphatidic acid receptor 1 L homeolog, anticorps LPAR1, anticorps Lpar1, anticorps lpar1, anticorps lpar1.S, anticorps lpar1.L

Sujet:

Background: Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA, this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).

Aliases: 5031439C20 antibody, AI326300 antibody, EDG 2 antibody, EDG2 antibody, Endothelial differentiation gene 2 antibody, Endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 2 antibody, GPCR 26 antibody, Gpcr26 antibody, Gpcr91 antibody, GPR26 antibody, Kdt2 antibody, LPA 1 antibody, LPA receptor 1 antibody, LPA receptor EDG2 antibody, LPA-1 antibody, lpA1 antibody, Lpar1 antibody, LPAR1_HUMAN antibody, Lysophosphatidic acid receptor 1 antibody, Lysophosphatidic acid receptor Edg-2 antibody, Lysophosphatidic acid receptor EDG2 antibody, MGC105279 antibody, MGC29102 antibody, Mrec1.3 antibody, rec.1.3 antibody, Ventricular zone gene 1 antibody, vzg-1 antibody, VZG1 antibody

UniProt: Q92633

Pathways: Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration