LAPTM4B anticorps (AA 174-226)

N° du produit ABIN7158792

Détail du produit anti-LAPTM4B anticorps

Antigène: LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))

Épitope: AA 174-226

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LAPTM4B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Lysosomal-associated transmembrane protein 4B protein (174-226AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur LAPTM4B

Antigène: LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))

Autre désignation: LAPTM4B (LAPTM4B Produits)

Synonymes: anticorps LAPTM4beta, anticorps LC27, anticorps C330023P13Rik, anticorps lysosomal protein transmembrane 4 beta, anticorps lysosomal-associated protein transmembrane 4B, anticorps LAPTM4B, anticorps Laptm4b

Sujet:

Background: Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).

Aliases: LAPTM4B antibody, PSEC0001 antibody, Lysosomal-associated transmembrane protein 4B antibody, Lysosome-associated transmembrane protein 4-beta antibody

UniProt: Q86VI4