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LAPTM4B anticorps (AA 174-226) (Biotin)

LAPTM4B Reactivité: Humain ELISA Hôte: Lapin Polyclonal Biotin
N° du produit ABIN7158793
  • Antigène Voir toutes LAPTM4B Anticorps
    LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))
    Épitope
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 174-226
    Reactivité
    • 13
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 13
    Lapin
    Clonalité
    • 13
    Polyclonal
    Conjugué
    • 10
    • 2
    • 1
    Cet anticorp LAPTM4B est conjugé à/à la Biotin
    Application
    • 10
    • 4
    • 4
    • 2
    • 1
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Lysosomal-associated transmembrane protein 4B protein (174-226AA)
    Isotype
    IgG
    Top Product
    Discover our top product LAPTM4B Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))
    Autre désignation
    LAPTM4B (LAPTM4B Produits)
    Synonymes
    anticorps LAPTM4beta, anticorps LC27, anticorps C330023P13Rik, anticorps lysosomal protein transmembrane 4 beta, anticorps lysosomal-associated protein transmembrane 4B, anticorps LAPTM4B, anticorps Laptm4b
    Sujet

    Background: Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).

    Aliases: LAPTM4B antibody, PSEC0001 antibody, Lysosomal-associated transmembrane protein 4B antibody, Lysosome-associated transmembrane protein 4-beta antibody

    UniProt
    Q86VI4
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