PRNP anticorps (AA 23-64)

N° du produit ABIN7158932

Détail du produit anti-PRNP anticorps

Antigène: PRNP (Prion Protein (PRNP))

Épitope: AA 23-64

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRNP est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Major prion protein (23-64AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PRNP

Antigène: PRNP (Prion Protein (PRNP))

Autre désignation: PRNP (PRNP Produits)

Synonymes: anticorps ASCR, anticorps AltPrP, anticorps CD230, anticorps CJD, anticorps GSS, anticorps KURU, anticorps PRIP, anticorps PrP, anticorps PrP27-30, anticorps PrP33-35C, anticorps PrPc, anticorps p27-30, anticorps Prn, anticorps Prn-p, anticorps prp, anticorps cjd, anticorps prion, anticorps prp(c), anticorps MGC84114, anticorps PRP, anticorps PRPC, anticorps Prp, anticorps SIP, anticorps PRNP, anticorps AA960666, anticorps AI325101, anticorps PrP, anticorps PrPC, anticorps PrPSc, anticorps Prn-i, anticorps Sinc, anticorps prP27-30, anticorps prP33-35C, anticorps PrP-1, anticorps PrP1, anticorps prnprs1, anticorps stPrP-1, anticorps zgc:123004, anticorps prion protein, anticorps prion protein S homeolog, anticorps prion protein b, anticorps PRNP, anticorps Prnp, anticorps prnp.S, anticorps prnpb

Sujet:

Background: Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as a agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

Aliases: Alternative prion protein, major prion protein antibody, AltPrP antibody, ASCR antibody, CD230 antibody, CD230 antigen antibody, CJD antibody, GSS antibody, KURU antibody, Major prion protein antibody, p27 30 antibody, PRIO_HUMAN antibody, Prion protein antibody, Prion related protein antibody, PRIP antibody, PRNP antibody, PrP antibody, PrP27 30 antibody, PrP27-30 antibody, PrP33-35C antibody, PrPC antibody, PrPSc antibody, Sinc antibody

UniProt: P04156

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation