RIKEN cDNA 4930404A10 Gene (4930404A10RIK) (AA 18-91) anticorps (FITC)

N° du produit ABIN7159185

Détail du produit

Antigène: RIKEN cDNA 4930404A10 Gene (4930404A10RIK)

Épitope: AA 18-91

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: FITC

Application: Veuillez nous consulter SVP

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Meiosis-specific kinetochore protein (18-91AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détail du antigène

Antigène: RIKEN cDNA 4930404A10 Gene (4930404A10RIK)

Autre désignation: MEIKIN (4930404A10RIK Produits)

Synonymes: anticorps 4930404A10Rik, anticorps meiotic kinetochore factor, anticorps Meikin

Sujet:

Background: Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.

Aliases: MEIKINMeiosis-specific kinetochore protein antibody

UniProt: A0A087WXM9