MAGEA2 anticorps (AA 1-104) (Biotin)

N° du produit ABIN7159257

Détail du produit anti-MAGEA2 anticorps (Biotin)

Antigène: MAGEA2 (Melanoma Antigen Family A, 2 (MAGEA2))

Épitope: AA 1-104

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAGEA2 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Melanoma-associated antigen 2 protein (1-104AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MAGEA2

Antigène: MAGEA2 (Melanoma Antigen Family A, 2 (MAGEA2))

Autre désignation: MAGEA2 (MAGEA2 Produits)

Synonymes: anticorps Mage-a2, anticorps MAGEA2, anticorps CT1.2, anticorps MAGE2, anticorps MAGEA2A, anticorps melanoma antigen, family A, 2, anticorps melanoma-associated antigen 2, anticorps MAGE family member A2, anticorps Magea2, anticorps LOC706218, anticorps MAGEA2

Sujet:

Background: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

Aliases: MAGEA2 antibody, MAGE2 antibody, MAGEA2A, antibody, MAGEA2B antibody, MAGE2 antibody, MAGEA2 antibody, Melanoma-associated antigen 2 antibody, Cancer/testis antigen 1.2 antibody, CT1.2 antibody, MAGE-2 antigen antibody

UniProt: P43356