MAVS anticorps (AA 1-65)

N° du produit ABIN7159830

Détail du produit anti-MAVS anticorps

Antigène: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Épitope: AA 1-65

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAVS est non-conjugé

Application: ELISA

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Mitochondrial antiviral-signaling protein (1-65AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MAVS

Antigène: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Autre désignation: MAVS (MAVS Produits)

Synonymes: anticorps CARDIF, anticorps IPS-1, anticorps IPS1, anticorps VISA, anticorps D430028G21Rik, anticorps Visa, anticorps cardif, anticorps wu:fj20d04, anticorps zgc:158392, anticorps mitochondrial antiviral signaling protein, anticorps MAVS, anticorps Mavs, anticorps mavs

Sujet:

Background: Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.

Aliases: CARD adapter inducing interferon beta antibody, CARD adaptor inducing IFN beta antibody, Cardif antibody, DKFZp666M015 antibody, FLJ27482 antibody, FLJ41962 antibody, IFN B promoter stimulator 1 antibody, Interferon beta promoter stimulator protein 1 antibody, Ips 1 antibody, IPS-1 antibody, Ips1 antibody, KIAA1271 antibody, MAVS antibody, MAVS_HUMAN antibody, Mitochondrial anti viral signaling protein antibody, Mitochondrial Antiviral Signaling antibody, Mitochondrial antiviral signaling protein antibody, Mitochondrial antiviral-signaling protein antibody, Putative NF kappa B activating protein 031N antibody, Putative NF-kappa-B-activating protein 031N antibody, Virus induced signaling adapter antibody, virus induced signaling adaptor antibody, Virus-induced-signaling adapter antibody, VISA antibody

UniProt: Q7Z434

Pathways: Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C