PLD6 anticorps (AA 1-252)

N° du produit ABIN7159837

Détail du produit anti-PLD6 anticorps

Antigène: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Épitope: AA 1-252

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLD6 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Mitochondrial cardiolipin hydrolase protein (1-252AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PLD6

Antigène: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Autre désignation: PLD6 (PLD6 Produits)

Synonymes: anticorps ZUC, anticorps 4933433K01Rik, anticorps Gm10, anticorps Zuc, anticorps mZuc, anticorps mitoPLD, anticorps pld6, anticorps fc55d08, anticorps wu:fc55d08, anticorps phospholipase D family member 6, anticorps phospholipase D family, member 6, anticorps phospholipase D family member 6 S homeolog, anticorps PLD6, anticorps Pld6, anticorps pld6.S, anticorps pld6

Sujet:

Background: Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol (PubMed:21397848). Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5\' phosphate and 3\' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Also acts as a regulator of mitochondrial shape through facilitating mitochondrial fusion (PubMed:17028579, PubMed:26711011).

Aliases: Choline phosphatase 6 antibody, Mitochondrial cardiolipin hydrolase antibody, Mitochondrial phospholipase antibody, MitoPLD antibody, Phosphatidylcholine hydrolyzing phospholipase D6 antibody, Phosphatidylcholine-hydrolyzing phospholipase D6 antibody, Phospholipase D family member 6 antibody, Phospholipase D6 antibody, PLD 6 antibody, pld6 antibody, PLD6_HUMAN antibody, Protein zucchini homolog antibody, ZUC antibody, Zucchini, Drosophila, homolog of antibody

UniProt: Q8N2A8

Pathways: Ribonucleoprotein Complex Subunit Organization