BUB1 anticorps (AA 256-577)

N° du produit ABIN7160084

Détail du produit anti-BUB1 anticorps

Antigène: BUB1 (Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1))

Épitope: AA 256-577

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BUB1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Mitotic checkpoint serine/threonine-protein kinase BUB1 protein (256-577AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur BUB1

Antigène: BUB1 (Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1))

Autre désignation: BUB1 (BUB1 Produits)

Synonymes: anticorps bub1a, anticorps bub1l, anticorps hbub1, anticorps xbub1, anticorps BUB1A, anticorps BUB1L, anticorps hBUB1, anticorps AL022991, anticorps Bub1a, anticorps C80208, anticorps D2Xrf87, anticorps BUB1 mitotic checkpoint serine/threonine kinase, anticorps BUB1, mitotic checkpoint serine/threonine kinase, anticorps BUB1, anticorps bub1, anticorps Bub1

Sujet:

Background: Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.

Aliases: Bub1 antibody, BUB1 budding uninhibited by benzimidazoles 1 homolog antibody, BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) antibody, BUB1 mitotic checkpoint serine/threonine kinase antibody, BUB1, S. cerevisiae, homolog of antibody, BUB1_HUMAN antibody, BUB1A antibody, BUB1L antibody, Budding uninhibited by benzimidazoles 1 (yeast homolog) antibody, Budding uninhibited by benzimidazoles 1 homolog antibody, Budding uninhibited by benzimidazoles 1, S. cerevisiae, homolog of antibody, hBUB1 antibody, Homolog of mitotic checkpoint gene BUB1 antibody, Mitotic checkpoint gene BUB1 antibody, Mitotic checkpoint serine/threonine protein kinase BUB1 antibody, Mitotic checkpoint serine/threonine-protein kinase BUB1 antibody, Mitotic spindle checkpoint kinase antibody, Putative serine/threonine protein kinase antibody

UniProt: O43683