MYLK anticorps (AA 290-398)

N° du produit ABIN7160538

Détail du produit anti-MYLK anticorps

Antigène: MYLK (Myosin Light Chain Kinase (MYLK))

Épitope: AA 290-398

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MYLK est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Myosin light chain kinase, smooth muscle protein (290-398AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MYLK

Antigène: MYLK (Myosin Light Chain Kinase (MYLK))

Autre désignation: MYLK (MYLK Produits)

Synonymes: anticorps AAT7, anticorps KRP, anticorps MLCK, anticorps MLCK1, anticorps MLCK108, anticorps MLCK210, anticorps MSTP083, anticorps MYLK1, anticorps smMLCK, anticorps 9530072E15Rik, anticorps A930019C19Rik, anticorps AW489456, anticorps Mlck, anticorps SMMLCK, anticorps mlck, anticorps fj60a06, anticorps mlck1a, anticorps mylk, anticorps wu:fj60a06, anticorps zmlck1, anticorps myosin light chain kinase, anticorps myosin, light polypeptide kinase, anticorps myosin, light chain kinase a, anticorps MYLK, anticorps Mylk, anticorps mylka

Sujet:

Background: Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury, triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis.

Aliases: deglutamylated form antibody, DKFZp686I10125 antibody, EC 2.7.11.18 antibody, FLJ12216 antibody, Kinase related protein antibody, Kinase-related protein antibody, KRP antibody, MLCK antibody, MLCK1 antibody, MLCK108 antibody, MLCK210 antibody, MSTP083 antibody, MYLK antibody, MYLK_HUMAN antibody, MYLK1 antibody, Myosin light chain kinase antibody, Myosin light polypeptide kinase antibody, OTTHUMP00000180642 antibody, OTTHUMP00000180643 antibody, s mMLCK antibody, smooth muscle antibody, Smooth muscle myosin light chain kinase antibody, Telokin antibody

UniProt: Q15746