DMPK anticorps (AA 243-424)

N° du produit ABIN7160623

Détail du produit anti-DMPK anticorps

Antigène: DMPK (Dystrophia Myotonica-Protein Kinase (DMPK))

Épitope: AA 243-424

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DMPK est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Myotonin-protein kinase protein (243-424AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DMPK

Antigène: DMPK (Dystrophia Myotonica-Protein Kinase (DMPK))

Autre désignation: DMPK (DMPK Produits)

Synonymes: anticorps DMPK, anticorps DM, anticorps DM1, anticorps DM1PK, anticorps DMK, anticorps MDPK, anticorps MT-PK, anticorps Dm15, anticorps DM1 protein kinase, anticorps dystrophia myotonica-protein kinase, anticorps DMPK, anticorps Dmpk

Sujet:

Background: Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.

Aliases: DM 1 antibody, DM antibody, DM kinase antibody, DM protein kinase antibody, DM-kinase antibody, DM1 antibody, DM1 protein kinase antibody, DM1PK antibody, DMK antibody, DMPK antibody, DMPK_HUMAN antibody, Dystrophia myotonica 1 antibody, Dystrophia myotonica protein kinase antibody, MDPK antibody, MT PK antibody, MT-PK antibody, Myotonic dystrophy associated protein kinase antibody, Myotonic dystrophy protein kinase antibody, Myotonin protein kinase A antibody, Myotonin protein kinase antibody, Myotonin-protein kinase antibody, Thymopoietin homolog antibody

UniProt: Q09013

Pathways: Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development