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GPR18 anticorps (AA 290-331)

GPR18 Reactivité: Humain WB, ELISA, IF, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7160749
  • Antigène Voir toutes GPR18 Anticorps
    GPR18 (G Protein-Coupled Receptor 18 (GPR18))
    Épitope
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 290-331
    Reactivité
    • 32
    • 12
    • 10
    • 5
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 33
    Lapin
    Clonalité
    • 33
    Polyclonal
    Conjugué
    • 26
    • 3
    • 2
    • 2
    Cet anticorp GPR18 est non-conjugé
    Application
    • 17
    • 15
    • 11
    • 10
    • 9
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)
     Réactivité croisée
    Humain, Souris
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human N-arachidonyl glycine receptor protein (290-331AA)
    Isotype
    IgG
  • Indications d'application
    Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    GPR18 (G Protein-Coupled Receptor 18 (GPR18))
    Autre désignation
    GPR18 (GPR18 Produits)
    Synonymes
    anticorps GPR18, anticorps G protein-coupled receptor 18, anticorps GPR18, anticorps Gpr18
    Sujet

    Background: Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937).

    Aliases: GPR18 antibody, GPCRWN-arachidonyl glycine receptor antibody, NAGly receptor antibody, G-protein coupled receptor 18 antibody

    UniProt
    Q14330
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