SETD8 anticorps (AA 136-258)

N° du produit ABIN7160766

Détail du produit anti-SETD8 anticorps

Antigène: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Épitope: AA 136-258

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SETD8 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human N-lysine methyltransferase KMT5A protein (136-258AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SETD8

Antigène: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Autre désignation: KMT5A (SETD8 Produits)

Synonymes: anticorps KMT5A, anticorps PR-Set7, anticorps SET07, anticorps SET8, anticorps 2410195B05Rik, anticorps AA617402, anticorps AW536475, anticorps PR-SET7, anticorps setd8b, anticorps wu:fc23f12, anticorps zgc:171649, anticorps Pr-set7, anticorps RGD1305893, anticorps Setd8, anticorps kmt5a, anticorps kmt5a-a, anticorps setd8, anticorps setd8-a, anticorps set8a, anticorps setd8a, anticorps wu:fj33f02, anticorps zgc:153719, anticorps lysine methyltransferase 5A, anticorps lysine methyltransferase 5Ab, anticorps lysine methyltransferase 5A S homeolog, anticorps lysine methyltransferase 5Aa, anticorps KMT5A, anticorps Kmt5a, anticorps kmt5ab, anticorps kmt5a.S, anticorps kmt5aa

Sujet:

Background: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates \\\'Lys-20\\\' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at \\\'Lys-382\\\', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.

Aliases: H4 K20 HMTase antibody, H4 K20 specific histone methyltransferase antibody, H4-K20-HMTase SETD8 antibody, Histone H4 K20 methyltransferase antibody, Histone lysine N methyltransferase H4 lysine 20 specific antibody, Histone-lysine N-methyltransferase SETD8 antibody, Lysine N-methyltransferase 5A antibody, N-lysine methyltransferase SETD8 antibody, Pr SET 7 antibody, Pr SET7 antibody, PR-Set7 antibody, PR/SET domain containing protein 07 antibody, PR/SET domain containing protein 8 antibody, PR/SET domain-containing protein 07 antibody, PR/SET07 antibody, PrSET7 antibody, SET 07 antibody, SET 8 antibody, SET domain containing (lysine methyltransferase) 8 antibody, SET domain containing 8 antibody, SET domain containing lysine methyltransferase 8 antibody, SET domain containing protein 8 antibody, SET domain-containing protein 8 antibody, SET07 antibody, SET8 antibody, SETD 8 antibody, setd8 antibody, SETD8_HUMAN antibody

UniProt: Q9NQR1