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NLRP6 anticorps (AA 154-306) (HRP)

NLRP6 Reactivité: Humain ELISA Hôte: Lapin Polyclonal HRP
N° du produit ABIN7160834
  • Antigène Voir toutes NLRP6 Anticorps
    NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))
    Épitope
    • 15
    • 10
    • 9
    • 8
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 154-306
    Reactivité
    • 33
    • 32
    • 18
    Humain
    Hôte
    • 61
    • 1
    Lapin
    Clonalité
    • 62
    • 1
    Polyclonal
    Conjugué
    • 21
    • 6
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NLRP6 est conjugé à/à la HRP
    Application
    • 36
    • 35
    • 13
    • 13
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human NACHT, LRR and PYD domains-containing protein 6 protein (154-306AA)
    Isotype
    IgG
    Top Product
    Discover our top product NLRP6 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))
    Autre désignation
    NLRP6 (NLRP6 Produits)
    Synonymes
    anticorps NLRP6, anticorps NALP6, anticorps AVR, anticorps CLR11.4, anticorps NAVR, anticorps NAVR/AVR, anticorps PAN3, anticorps PYPAF5, anticorps AI504961, anticorps Avr, anticorps Nalp6, anticorps Navr, anticorps Navr/Avr, anticorps Pypaf5, anticorps NLR family pyrin domain containing 6, anticorps NLR family, pyrin domain containing 6, anticorps NLRP6, anticorps Nlrp6
    Sujet

    Background: As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity) (PubMed:12387869). Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity).

    Aliases: Angiotensin II/vasopressin receptor antibody, AVR antibody, CLR11.4 antibody, NACHT, leucine rich repeat and PYD containing 6 antibody, NACHT, LRR and PYD containing protein 6 antibody, NACHT, LRR and PYD domains-containing protein 6 antibody, NAVR antibody, NAVR/AVR antibody, NLR family, pyrin domain containing 6 antibody, Nlrp6 antibody, NLRP6_HUMAN antibody, Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 6 antibody, PAN3 antibody, PYPAF5 antibody, PYRIN containing APAF1 like protein 5 antibody, PYRIN-containing APAF1-like protein 5 antibody

    UniProt
    P59044
    Pathways
    Inflammasome
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