SIRT7 anticorps (AA 242-379)

N° du produit ABIN7160866

Détail du produit anti-SIRT7 anticorps

Antigène: SIRT7 (Sirtuin 7 (SIRT7))

Épitope: AA 242-379

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIRT7 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human NAD-dependent protein deacetylase sirtuin-7 protein (242-379AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SIRT7

Antigène: SIRT7 (Sirtuin 7 (SIRT7))

Autre désignation: SIRT7 (SIRT7 Produits)

Synonymes: anticorps SIRT7, anticorps LOC796135, anticorps SIR2L7, anticorps sirtuin 7, anticorps phosphate cytidylyltransferase 2, ethanolamine, anticorps SIRT7, anticorps sirt7, anticorps PCYT2, anticorps Sirt7

Sujet:

Background: NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at \'Lys-18\' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.

Aliases: NAD dependent deacetylase sirtuin 7 antibody, NAD dependent protein deacetylase sirtuin 7 antibody, NAD-dependent protein deacetylase sirtuin-7 antibody, Regulatory protein SIR2 homolog 7 antibody, Silent mating type information regulation 2 homolog antibody, Silent mating type information regulation 2 S.cerevisiae homolog 7 antibody, SIR2 L7 antibody, SIR2 like protein 7 antibody, Sir2 related protein type 7 antibody, SIR2, S.CEREVISIAE, HOMOLOG-LIKE 7 antibody, SIR2-like protein 7 antibody, SIR2L 7 antibody, SIR2L7 antibody, SIR7_HUMAN antibody, SIRT 7 antibody, SIRT7 antibody, Sirtuin 7 antibody, Sirtuin type 7 antibody, Sirtuin7 antibody

UniProt: Q9NRC8