NPHP4 anticorps (AA 397-543)

N° du produit ABIN7161158

Détail du produit anti-NPHP4 anticorps

Antigène: NPHP4 (Nephronophthisis 4 (NPHP4))

Épitope: AA 397-543

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPHP4 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Nephrocystin-4 protein (397-543AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NPHP4

Antigène: NPHP4 (Nephronophthisis 4 (NPHP4))

Autre désignation: NPHP4 (NPHP4 Produits)

Synonymes: anticorps NPHP4, anticorps POC10, anticorps SLSN4, anticorps 4930564O18Rik, anticorps nmf192, anticorps nephrocystin 4, anticorps nephrocystin-4, anticorps nephronophthisis 4 (juvenile) homolog (human), anticorps NPHP4, anticorps LOC100184720, anticorps Nphp4

Sujet:

Background: Involved in the organization of apical junctions, the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462).

Aliases: KIAA0673 antibody, Nephrocystin-4 antibody, nephronophthisis 4 antibody, Nephroretinin antibody, NPHP4 antibody, NPHP4_HUMAN antibody, POC10 antibody, POC10 centriolar protein homolog antibody, SLSN4 antibody

UniProt: O75161