UNC5B anticorps (AA 404-517)

N° du produit ABIN7161183

Détail du produit anti-UNC5B anticorps

Antigène: UNC5B (Netrin receptor UNC5B (UNC5B))

Épitope: AA 404-517

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UNC5B est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Netrin receptor UNC5B protein (404-517AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur UNC5B

Antigène: UNC5B (Netrin receptor UNC5B (UNC5B))

Autre désignation: UNC5B (UNC5B Produits)

Synonymes: anticorps unc5h2, anticorps 6330415E02Rik, anticorps A630020F16, anticorps D10Bwg0792e, anticorps Unc5h2, anticorps UNC5H2, anticorps p53RDL1, anticorps UNC5C, anticorps UNC5B, anticorps p53rdl1, anticorps unc-5 netrin receptor B, anticorps unc-5 netrin receptor B L homeolog, anticorps unc5b, anticorps Unc5b, anticorps UNC5B, anticorps unc5b.L

Sujet:

Background: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).

Aliases: 6330415E02Rik antibody, A630020F16 antibody, D10Bwg0792e antibody, Netrin receptor UNC5B antibody, Netrin receptor UNC5B Precursor antibody, p53 regulated receptor for death and life antibody, p53 regulated receptor for death and life protein 1 antibody, p53-regulated receptor for death and life protein 1 antibody, p53RDL1 antibody, Protein unc-5 homolog 2 antibody, Protein unc-5 homolog B antibody, Protein XUNC 5 antibody, Transmembrane receptor Unc5H2 antibody, Unc 5 homolog 2 antibody, Unc 5 homolog B antibody, Unc 5 netrin receptor B antibody, UNC 5B antibody, Unc5 (C.elegans homolog) b antibody, Unc5b antibody, UNC5B_HUMAN antibody, UNC5H2 antibody

UniProt: Q8IZJ1