NPAS4 anticorps (AA 445-585)

N° du produit ABIN7161390

Détail du produit anti-NPAS4 anticorps

Antigène: NPAS4 (Neuronal PAS Domain Protein 4 (NPAS4))

Épitope: AA 445-585

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPAS4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Neuronal PAS domain-containing protein 4 protein (445-585AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NPAS4

Antigène: NPAS4 (Neuronal PAS Domain Protein 4 (NPAS4))

Autre désignation: NPAS4 (NPAS4 Produits)

Synonymes: anticorps LE-PAS, anticorps Nxf, anticorps Le-PAS, anticorps NXF, anticorps PASD10, anticorps bHLHe79, anticorps npas4, anticorps wu:fj52d04, anticorps zgc:136764, anticorps MGC146621, anticorps neuronal PAS domain protein 4, anticorps neuronal PAS domain protein 4a, anticorps neuronal PAS domain-containing protein 4, anticorps Npas4, anticorps NPAS4, anticorps npas4a, anticorps npas4, anticorps Tsp_02837

Sujet:

Background: Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (By similarity). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734). Can activate the CME (CNS midline enhancer) element (PubMed:14701734).

Aliases: bHLH PAS type transcription factor NXF antibody, bHLHe79 antibody, Class E basic helix-loop-helix protein 79 antibody, HLH-PAS transcription factor NXF antibody, Le PAS antibody, limbic enhanced PAS protein antibody, neuronal PAS domain protein 4 antibody, Neuronal PAS domain-containing protein 4 antibody, Neuronal PAS4 antibody, NPAS4 antibody, NPAS4_HUMAN antibody, NXF antibody, PAS domain-containing protein 10 antibody, PASD10 antibody

UniProt: Q8IUM7