ULBP2 anticorps (AA 26-216)

N° du produit ABIN7161653

Détail du produit anti-ULBP2 anticorps

Antigène: ULBP2 (UL16 Binding Protein 2 (ULBP2))

Épitope: AA 26-216

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ULBP2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human NKG2D ligand 2 protein (26-216AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ULBP2

Antigène: ULBP2 (UL16 Binding Protein 2 (ULBP2))

Autre désignation: ULBP2 (ULBP2 Produits)

Synonymes: anticorps N2DL2, anticorps RAET1H, anticorps UL16 binding protein 2, anticorps NKG2D ligand 2-like, anticorps ULBP2, anticorps LOC100355436

Sujet:

Background: Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Aliases: ALCAN alpha antibody, ALCAN-alpha antibody, N2DL 2 antibody, N2DL-2 antibody, N2DL2 antibody, N2DL2_HUMAN antibody, NKG2D ligand 2 antibody, NKG2D ligand 2 precursor antibody, NKG2DL2 antibody, RAET1H antibody, Retinoic acid early transcript 1 H antibody, Retinoic acid early transcript 1H antibody, UL16 binding protein 2 antibody, UL16-binding protein 2 antibody, ULBP2 antibody

UniProt: Q9BZM5