Norrie Disease (Pseudoglioma) anticorps (AA 25-133)

N° du produit ABIN7161709

Détail du produit anti-Norrie Disease (Pseudoglioma) anticorps

Antigène: Norrie Disease (Pseudoglioma) (NDP)

Épitope: AA 25-133

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Norrie Disease (Pseudoglioma) est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Norrin protein (25-133AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Norrie Disease (Pseudoglioma)

Antigène: Norrie Disease (Pseudoglioma) (NDP)

Autre désignation: NDP (NDP Produits)

Synonymes: anticorps EVR2, anticorps FEVR, anticorps ND, anticorps evr2, anticorps fevr, anticorps xnorrin, anticorps Ndph, anticorps RGD1563968, anticorps NDP, norrin cystine knot growth factor, anticorps Norrie disease (pseudoglioma) L homeolog, anticorps Norrie disease (pseudoglioma) (human), anticorps NDP, anticorps ndp.L, anticorps Ndp

Sujet:

Background: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

Aliases: EVR2 antibody, Exudative vitreoretinopathy 2 (X linked) antibody, FEVR antibody, ND antibody, NDP antibody, NDP_HUMAN antibody, Norrie disease (pseudoglioma) antibody, Norrie disease protein antibody, Norrin antibody, Norrin precursor antibody, X linked exudative vitreoretinopathy 2 protein antibody, X-linked exudative vitreoretinopathy 2 protein antibody

UniProt: Q00604

Pathways: Sensory Perception of Sound