NUAK1 anticorps (AA 442-573)

N° du produit ABIN7161742

Détail du produit anti-NUAK1 anticorps

Antigène: NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))

Épitope: AA 442-573

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUAK1 est non-conjugé

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human NUAK family SNF1-like kinase 1 protein (442-573AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NUAK1

Antigène: NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))

Autre désignation: NUAK1 (NUAK1 Produits)

Synonymes: anticorps ARK5, anticorps AU014801, anticorps AW494241, anticorps B230104P22Rik, anticorps Omphk1, anticorps NUAK family kinase 1, anticorps NUAK family, SNF1-like kinase, 1, anticorps NUAK1, anticorps Nuak1

Sujet:

Background: Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of \'Ser-464\' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at \'Ser-15\' and \'Ser-392\' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).

Aliases: NUAK1 antibody, ARK5 antibody, KIAA0537 antibody, OMPHK1 antibody, NUAK family SNF1-like kinase 1 antibody, EC 2.7.11.1 antibody, AMPK-related protein kinase 5 antibody, ARK5 antibody, Omphalocele kinase 1 antibody

UniProt: O60285