Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

NME4 anticorps (AA 1-187)

NME4 Reactivité: Humain IHC, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7162056
  • Antigène Voir toutes NME4 Anticorps
    NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4 (NME4))
    Épitope
    • 15
    • 7
    • 7
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-187
    Reactivité
    • 39
    • 20
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 49
    • 8
    Lapin
    Clonalité
    • 51
    • 6
    Polyclonal
    Conjugué
    • 27
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NME4 est non-conjugé
    Application
    • 48
    • 20
    • 18
    • 13
    • 13
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Immunohistochemistry (IHC), ELISA
     Réactivité croisée
    Humain
    Purification
    Antigen Affinity Purified
    Immunogène
    Recombinant Human Nucleoside diphosphate kinase, mitochondrial protein (1-187AA)
    Isotype
    IgG
    Top Product
    Discover our top product NME4 Anticorps primaire
  • Indications d'application
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4 (NME4))
    Autre désignation
    NME4 (NME4 Produits)
    Synonymes
    anticorps NDPK-D, anticorps NM23H4, anticorps nm23-H4, anticorps 2610027N22Rik, anticorps 2810024O08Rik, anticorps 5730493H09Rik, anticorps NM23-M4, anticorps Nm23M4, anticorps NME/NM23 nucleoside diphosphate kinase 4, anticorps NME4, anticorps Nme4
    Sujet

    Background: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin, the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK, its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663).

    Aliases: metastatic inhibition factor NM23H4 antibody, mitochondrial antibody, NDK antibody, NDKM_HUMAN antibody, NDP kinase antibody, NDP kinase D antibody, NDP kinase, mitochondrial antibody, NDPK D antibody, NDPKD antibody, nm23 H4 antibody, nm23-H4 antibody, NM23D antibody, NM23H4 antibody, Nm23M4 antibody, NME/NM23 nucleoside diphosphate kinase 4 antibody, NME4 antibody, Non metastatic cells 4 protein expressed in antibody, Non metastatic protein 23, homolog 4 antibody, Nucleoside diphosphate kinase D antibody, Nucleoside diphosphate kinase, mitochondrial antibody, Nucleoside diphosphate kinase, mitochondrial antibody

    UniProt
    O00746
    Pathways
    Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process
Vous êtes ici:
Support technique