NOD2 anticorps (AA 460-733)

N° du produit ABIN7162073

Détail du produit anti-NOD2 anticorps

Antigène: NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))

Épitope: AA 460-733

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOD2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Nucleotide-binding oligomerization domain-containing protein 2 protein (460-733AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NOD2

Antigène: NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))

Autre désignation: NOD2 (NOD2 Produits)

Synonymes: anticorps ACUG, anticorps BLAU, anticorps CARD15, anticorps CD, anticorps CLR16.3, anticorps IBD1, anticorps NLRC2, anticorps NOD2B, anticorps PSORAS1, anticorps Card15, anticorps F830032C23Rik, anticorps Nlrc2, anticorps caspase recruitment domain 15 protein, anticorps nucleotide binding oligomerization domain containing 2, anticorps nucleotide-binding oligomerization domain containing 2, anticorps TTHERM_01951320, anticorps NOD2, anticorps Nod2

Sujet:

Background: Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).

Aliases: ACUG antibody, Arthrocutaneouveal granulomatosis antibody, BLAU antibody, CARD15 antibody, Caspase recruitment domain family, member 15 antibody, Caspase recruitment domain protein 15 antibody, Caspase recruitment domain-containing protein 15 antibody, CD antibody, CLR16.3 antibody, IBD1 antibody, Inflammatory bowel disease protein 1 antibody, LRR containing protein antibody, NLR family, CARD domain containing 2 antibody, NLRC2 antibody, NOD like receptor C2 antibody, NOD2 antibody, NOD2 protein antibody, NOD2_HUMAN antibody, NOD2B antibody, nucleotide binding oligomerization domain 2 antibody, Nucleotide binding oligomerization domain containing 2 antibody, Nucleotide binding oligomerization domain, leucine rich repeat and CARD domain containing 2 antibody, Nucleotide-binding oligomerization domain-containing protein 2 antibody, PSORAS1 antibody

UniProt: Q9HC29

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome