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OTUD7B anticorps (AA 235-347) (HRP)

OTUD7B Reactivité: Humain ELISA Hôte: Lapin Polyclonal HRP
N° du produit ABIN7162341
  • Antigène Voir toutes OTUD7B Anticorps
    OTUD7B (OTU Domain Containing 7B (OTUD7B))
    Épitope
    • 9
    • 9
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 235-347
    Reactivité
    • 39
    • 14
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 35
    • 4
    Lapin
    Clonalité
    • 37
    • 2
    Polyclonal
    Conjugué
    • 19
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp OTUD7B est conjugé à/à la HRP
    Application
    • 28
    • 21
    • 20
    • 4
    • 3
    • 1
    • 1
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human OTU domain-containing protein 7B protein (235-347AA)
    Isotype
    IgG
    Top Product
    Discover our top product OTUD7B Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    OTUD7B (OTU Domain Containing 7B (OTUD7B))
    Autre désignation
    OTUD7B (OTUD7B Produits)
    Synonymes
    anticorps OTUD7B, anticorps ZA20D1, anticorps za20d1, anticorps zgc:152772, anticorps cezanne, anticorps CEZANNE, anticorps 2900060B22Rik, anticorps 4930463P07Rik, anticorps AI462125, anticorps Trabid2, anticorps Za20d1, anticorps RGD1308111, anticorps OTU deubiquitinase 7B, anticorps OTU domain containing 7B, anticorps OTUD7B, anticorps otud7b, anticorps Otud7b
    Sujet

    Background: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates \'Lys-48\'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward \'Lys-11\', \'Lys-48\' and \'Lys-63\'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with \'Lys-11\'-linked polyubiquitin chains (in vitro), however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.

    Aliases: Cellular zinc finger anti NF kappa B protein antibody, Cellular zinc finger anti-NF-kappa-B protein antibody, CEZANNE antibody, HGNC:16683 antibody, OTU domain containing protein 7B antibody, OTU domain-containing protein 7B antibody, OTU7B_HUMAN antibody, OTUD7B antibody, ZA20D1 antibody, Zinc finger A20 domain containing protein 1 antibody, Zinc finger A20 domain-containing protein 1 antibody, Zinc finger protein Cezanne antibody

    UniProt
    Q6GQQ9
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