OSBP anticorps (AA 628-802)

N° du produit ABIN7162395

Détail du produit anti-OSBP anticorps

Antigène: OSBP (Oxysterol Binding Protein (OSBP))

Épitope: AA 628-802

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OSBP est non-conjugé

Application: ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Oxysterol-binding protein 1 protein (628-802AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur OSBP

Antigène: OSBP (Oxysterol Binding Protein (OSBP))

Autre désignation: OSBP (OSBP Produits)

Synonymes: anticorps CG6708, anticorps Dmel\\CG6708, anticorps OSBP-Dm, anticorps osbp, anticorps OSBP1, anticorps 1110018F06Rik, anticorps AW559088, anticorps mKIAA4220, anticorps Oxysterol binding protein, anticorps oxysterol binding protein, anticorps Osbp, anticorps OSBP

Sujet:

Background: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749).

Aliases: OSBP 1 antibody, OSBP antibody, OSBP1_HUMAN antibody, Oxysterol binding protein 1 antibody, Oxysterol-binding protein 1 antibody

UniProt: P22059