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HRPT2 anticorps (AA 74-346)

CDC73 Reactivité: Humain ELISA, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7162615
  • Antigène Voir toutes HRPT2 (CDC73) Anticorps
    HRPT2 (CDC73) (Parafibromin (CDC73))
    Épitope
    • 15
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 74-346
    Reactivité
    • 45
    • 9
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 45
    • 1
    Lapin
    Clonalité
    • 46
    Polyclonal
    Conjugué
    • 18
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HRPT2 est non-conjugé
    Application
    • 27
    • 20
    • 14
    • 14
    • 13
    • 13
    • 13
    • 4
    • 3
    • 3
    ELISA, Immunofluorescence (IF)
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Parafibromin protein (74-346AA)
    Isotype
    IgG
    Top Product
    Discover our top product CDC73 Anticorps primaire
  • Indications d'application
    Recommended dilution: IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    HRPT2 (CDC73) (Parafibromin (CDC73))
    Autre désignation
    CDC73 (CDC73 Produits)
    Synonymes
    anticorps C1orf28, anticorps HPTJT, anticorps HRPT2, anticorps HYX, anticorps 8430414L16Rik, anticorps BC027756, anticorps C130030P16Rik, anticorps C81219, anticorps Hrpt2, anticorps hrpt2, anticorps zgc:63956, anticorps MGC108428, anticorps cdc73, anticorps LOC100222932, anticorps cell division cycle 73, anticorps cell division cycle 73, Paf1/RNA polymerase II complex component, anticorps cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae), anticorps parafibromin, anticorps cell division cycle 73 S homeolog, anticorps CDC73, anticorps Cdc73, anticorps cdc73, anticorps Tsp_03925, anticorps Tsp_04052, anticorps Tsp_04125, anticorps cdc73.S
    Sujet

    Background: Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and \\\'Ser-2\\\'- and \\\'Ser-5\\\'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1, it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 \\\'Lys-4\\\' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of \\\'Lys-120\\\' of histone H2B (H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3\\\' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors.

    Aliases: C1orf28 antibody, CDC 73 antibody, Cdc73 antibody, CDC73_HUMAN antibody, Cell division cycle 73 antibody, Cell division cycle 73 Paf1/RNA polymerase II complex component homolog antibody, Cell division cycle 73 Paf1/RNA polymerase II complex component like protein antibody, Cell division cycle protein 73 homolog antibody, FIHP antibody, FLJ23316 antibody, HPT JT antibody, HPTJT antibody, HRPT 2 antibody, HRPT1 antibody, HRPT2 antibody, Hyperparathyroidism 2 (with jaw tumor) antibody, Hyperparathyroidism 2 antibody, Hyperparathyroidism 2 protein antibody, HYX antibody, Paf1/RNA polymerase II complex component antibody, Parafibromin antibody

    UniProt
    Q6P1J9
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance
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