PAXIP1 anticorps (AA 613-812) (HRP)

N° du produit ABIN7162705

Détail du produit anti-PAXIP1 anticorps (HRP)

Antigène: PAXIP1 (PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1))

Épitope: AA 613-812

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAXIP1 est conjugé à/à la HRP

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human PAX-interacting protein 1 protein (613-812AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PAXIP1

Antigène: PAXIP1 (PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1))

Autre désignation: PAXIP1 (PAXIP1 Produits)

Synonymes: anticorps CAGF29, anticorps PACIP1, anticorps PAXIP1L, anticorps PTIP, anticorps TNRC2, anticorps wu:fa04b06, anticorps zgc:92593, anticorps cagf28, anticorps cagf29, anticorps k14, anticorps pacip1, anticorps paxip1l, anticorps ptip, anticorps tnrc2, anticorps D5Ertd149e, anticorps PAX interacting protein 1, anticorps PAX interacting (with transcription-activation domain) protein 1, anticorps PAX interacting protein 1 L homeolog, anticorps PAXIP1, anticorps paxip1, anticorps paxip1.L, anticorps Paxip1

Sujet:

Background: Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at \'Ser-25\'. Together with TP53BP1 regulates ATM association. Recruits PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage, the function is probbaly independent of MLL-containing histone methyltransferase (HMT) complexes. Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at \'Lys-4\' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus, this function appears to involve the recruitment of MLL-containing HMT complexes.

Aliases: CAGF 28 antibody, CAGF 29 antibody, CAGF28 antibody, CAGF29 antibody, FLJ41049 antibody, PACIP 1 antibody, PACIP1 antibody, PAX interacting (with transcription activation domain) protein 1 antibody, PAX interacting protein 1 antibody, PAX transactivation activation domain-interacting protein antibody, PAX transcription activation domain interacting protein 1 like antibody, PAX-interacting protein 1 antibody, PAXI1_HUMAN antibody, PAXIP 1 antibody, PAXIP 1L antibody, paxip1 antibody, PAXIP1 protein antibody, PAXIP1L antibody, Protein encoded by CAG trinucleotide repeats antibody, PTIP antibody, TNRC 2 antibody, TNRC2 antibody

UniProt: Q6ZW49

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response