PHAX anticorps (AA 6-243) (Biotin)
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- Antigène Voir toutes PHAX Anticorps
- PHAX (phosphorylated Adaptor For RNA Export (PHAX))
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Épitope
- AA 6-243
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PHAX est conjugé à/à la Biotin
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Application
- ELISA
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human Phosphorylated adapter RNA export protein (6-243AA)
- Isotype
- IgG
- Top Product
- Discover our top product PHAX Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- PHAX (phosphorylated Adaptor For RNA Export (PHAX))
- Autre désignation
- PHAX (PHAX Produits)
- Synonymes
- anticorps RNUXA, anticorps 2810055C14Rik, anticorps 4933427L19Rik, anticorps AU018701, anticorps AU018854, anticorps D18Ertd65e, anticorps Rnuxa, anticorps p55, anticorps phosphorylated adaptor for RNA export, anticorps PHAX, anticorps Phax
- Sujet
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Background: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.
Aliases: FLJ13193 antibody, PHAX antibody, PHAX_HUMAN antibody, Phosphorylated adapter RNA export protein antibody, Phosphorylated adaptor for RNA export antibody, RNA U small nuclear RNA export adapter protein antibody, RNA U, small nuclear RNA export adapter (phosphorylation regulated) antibody, RNUXA antibody
- UniProt
- Q9H814
- Pathways
- Ribonucleoprotein Complex Subunit Organization
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