PITX3 anticorps (AA 10-200)

N° du produit ABIN7163469

Détail du produit anti-PITX3 anticorps

Antigène: PITX3 (Pituitary Homeobox 3 (PITX3))

Épitope: AA 10-200

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PITX3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Pituitary homeobox 3 protein (10-200AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PITX3

Antigène: PITX3 (Pituitary Homeobox 3 (PITX3))

Autre désignation: PITX3 (PITX3 Produits)

Synonymes: anticorps CTPP4, anticorps CTRCT11, anticorps PTX3, anticorps pitx3, anticorps Ptx3, anticorps ak, anticorps zgc:109716, anticorps pitx3-A, anticorps xPitx3, anticorps paired like homeodomain 3, anticorps paired-like homeodomain 3, anticorps paired like homeodomain 3 L homeolog, anticorps paired-like homeodomain transcription factor 3, anticorps paired-like homeodomain transcription factor Pitx3, anticorps PITX3, anticorps Pitx3, anticorps pitx3.L, anticorps pitx3

Sujet:

Background: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).

Aliases: Homeobox protein PITX 3 antibody, Homeobox protein PITX3 antibody, MGC12766 antibody, Paired like homeodomain transcription factor 3 antibody, Paired-like homeodomain transcription factor 3 antibody, Pituitary homeobox 3 antibody, PITX 3 antibody, Pitx3 antibody, PITX3_HUMAN antibody, PTX 3 antibody, PTX3 antibody

UniProt: O75364