PIWIL4 anticorps (AA 12-235)

N° du produit ABIN7163478

Détail du produit anti-PIWIL4 anticorps

Antigène: PIWIL4 (Piwi-Like 4 (PIWIL4))

Épitope: AA 12-235

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIWIL4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Piwi-like protein 4 protein (12-235AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PIWIL4

Antigène: PIWIL4 (Piwi-Like 4 (PIWIL4))

Autre désignation: PIWIL4 (PIWIL4 Produits)

Synonymes: anticorps HIWI2, anticorps MIWI2, anticorps 9230101H05Rik, anticorps Miwi2, anticorps piwi like RNA-mediated gene silencing 4, anticorps piwi-like RNA-mediated gene silencing 4, anticorps PIWIL4, anticorps Piwil4

Sujet:

Background: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association. The piRNA process acts upstream of known mediators of DNA methylation. Participates in a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). May be involved in the chromatin-modifying pathway by inducing \\\'Lys-9\\\' methylation of histone H3 at some loci (PubMed:12906857).

Aliases: DKFZp686P01248 antibody, FLJ36156 antibody, HILI 2 antibody, HILI2 antibody, HIWI 2 antibody, HIWI2 antibody, Miwi 2 protein antibody, Miwi2 antibody, PIWI antibody, Piwi like 2 antibody, Piwi like 4 (Drosophila) antibody, Piwi like 4 antibody, Piwi like protein 4 antibody, PIWI like protein antibody, Piwi like RNA mediated gene silencing 4 antibody, Piwi-like protein 4 antibody, PIWIL 4 antibody, Piwil4 antibody, PIWL4_HUMAN antibody

UniProt: Q7Z3Z4