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PCGF1 anticorps (AA 113-187) (Biotin)

PCGF1 Reactivité: Humain ELISA Hôte: Lapin Polyclonal Biotin
N° du produit ABIN7163795
  • Antigène Voir toutes PCGF1 Anticorps
    PCGF1 (Polycomb Group Ring Finger 1 (PCGF1))
    Épitope
    • 15
    • 15
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 113-187
    Reactivité
    • 29
    • 19
    • 19
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 43
    • 1
    Lapin
    Clonalité
    • 44
    Polyclonal
    Conjugué
    • 12
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp PCGF1 est conjugé à/à la Biotin
    Application
    • 40
    • 26
    • 26
    • 11
    • 6
    • 6
    • 2
    • 1
    • 1
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Polycomb group RING finger protein 1 protein (113-187AA)
    Isotype
    IgG
    Top Product
    Discover our top product PCGF1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    PCGF1 (Polycomb Group Ring Finger 1 (PCGF1))
    Autre désignation
    PCGF1 (PCGF1 Produits)
    Synonymes
    anticorps PCGF1, anticorps 2010002K04Rik, anticorps NSPC1, anticorps RNF3A-2, anticorps RNF68, anticorps AU024121, anticorps Nspc1, anticorps nspc1, anticorps si:zc207o21.2, anticorps polycomb group ring finger 1, anticorps polycomb group ring finger 1 L homeolog, anticorps PCGF1, anticorps pcgf1, anticorps Pcgf1, anticorps pcgf1.L
    Sujet

    Background: Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6, this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A \'Lys-119\', rendering chromatin heritably changed in its expressibility. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479).

    Aliases: PCGF1 antibody, NSPC1 antibody, RNF68 antibody, Polycomb group RING finger protein 1 antibody, Nervous system Polycomb-1 antibody, NSPc1 antibody, RING finger protein 68 antibody

    UniProt
    Q9BSM1
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