DHX58 anticorps (AA 389-678)

N° du produit ABIN7164384

Détail du produit anti-DHX58 anticorps

Antigène: DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))

Épitope: AA 389-678

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DHX58 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Rat

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Probable ATP-dependent RNA helicase DHX58 protein (389-678AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DHX58

Antigène: DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))

Autre désignation: DHX58 (DHX58 Produits)

Synonymes: anticorps MGC82787, anticorps DHX58, anticorps lgp2, anticorps D11LGP2, anticorps D11lgp2e, anticorps LGP2, anticorps RLR-3, anticorps B430001I08Rik, anticorps D11Lgp2e, anticorps LPG2, anticorps Lgp2, anticorps RGD1310093, anticorps DEXH-box helicase 58 L homeolog, anticorps DExH-box helicase 58, anticorps probable ATP-dependent RNA helicase DHX58, anticorps DEXH (Asp-Glu-X-His) box polypeptide 58, anticorps DEXH-box helicase 58, anticorps dhx58.L, anticorps DHX58, anticorps dhx58, anticorps LOC100566102, anticorps Dhx58

Sujet:

Background: Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5\\\'-triphosphorylated RNA, although it can recognize RNA lacking a 5\\\'-triphosphate.

Aliases: D11LGP2 antibody, D11lgp2e antibody, DEXH (Asp Glu X His) box polypeptide 58 antibody, DEXH box polypeptide 58 antibody, DHX 58 antibody, DHX58 antibody, DHX58_HUMAN antibody, LGP 2 antibody, LGP2 antibody, Ortholog of mouse D11lgp2 antibody, Probable ATP dependent helicase LGP2 antibody, Probable ATP dependent RNA helicase DHX58 antibody, Probable ATP-dependent helicase LGP2 antibody, Probable ATP-dependent RNA helicase DHX58 antibody, Protein D11Lgp2 homolog antibody, RIG-I-like receptor LGP2 antibody, RLR antibody, RNA helicase LGP2 antibody

UniProt: Q96C10