PSMB8 anticorps (AA 176-276) (HRP)
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- Antigène Voir toutes PSMB8 Anticorps
- PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))
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Épitope
- AA 176-276
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PSMB8 est conjugé à/à la HRP
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Application
- ELISA
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human Proteasome subunit beta type-8 protein (176-276AA)
- Isotype
- IgG
- Top Product
- Discover our top product PSMB8 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))
- Autre désignation
- PSMB8 (PSMB8 Produits)
- Synonymes
- anticorps ALDD, anticorps D6S216, anticorps D6S216E, anticorps JMP, anticorps LMP7, anticorps NKJO, anticorps PSMB5i, anticorps RING10, anticorps ATP6V0D2, anticorps lmp7, anticorps prosome, anticorps macropain, anticorps Lmp-7, anticorps Lmp7, anticorps Ring10, anticorps proteasome subunit beta 8, anticorps proteasome subunit beta 8A, anticorps proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7), anticorps PSMB8, anticorps psmb8a, anticorps Psmb8
- Sujet
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Background: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH . The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.
Aliases: ALDD antibody, D6S216 antibody, D6S216E antibody, Large multifunctional peptidase 7 antibody, Large multifunctional protease 7 antibody, LMP 7 antibody, LMP7 antibody, Low molecular mass protein 7 antibody, Low molecular weight protein 7 antibody, Macropain subunit C13 antibody, MGC1491 antibody, Multicatalytic endopeptidase complex subunit C13 antibody, NKJO antibody, OTTHUMP00000062981 antibody, Protease component C13 antibody, Proteasome (prosome macropain) subunit beta type 8 antibody, Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) antibody, Proteasome beta 8 subunit antibody, Proteasome catalytic subunit 3i antibody, Proteasome component C13 antibody, Proteasome related gene 7 antibody, Proteasome subunit beta 5i antibody, Proteasome subunit beta 8 antibody, Proteasome subunit beta type 8 antibody, Proteasome subunit beta type antibody, Proteasome subunit beta type-8 antibody, Proteasome subunit beta-5i antibody, Proteasome subunit Y2 antibody, PSB8_HUMAN antibody, PSMB 8 antibody, PSMB5i antibody, PSMB8 antibody, Really interesting new gene 10 protein antibody, RING 10 antibody, RING10 antibody, Y2 antibody
- UniProt
- P28062
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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