POT1 anticorps (AA 250-432)

N° du produit ABIN7164998

Détail du produit anti-POT1 anticorps

Antigène: POT1 (Protection of Telomeres 1 (POT1))

Épitope: AA 250-432

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POT1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Protection of telomeres protein 1 protein (250-432AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur POT1

Antigène: POT1 (Protection of Telomeres 1 (POT1))

Autre désignation: POT1 (POT1 Produits)

Synonymes: anticorps HPOT1, anticorps POT1, anticorps DKFZp469P1825, anticorps pot1, anticorps 1500031H18Rik, anticorps AI851169, anticorps Pot1, anticorps Pot1a, anticorps protection of telomeres 1, anticorps protection of telomeres 1 L homeolog, anticorps protection of telomeres 1A, anticorps POT1, anticorps pot1.L, anticorps Pot1a, anticorps Pot1

Sujet:

Background: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5\'-TTAGGG-3\' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5\'-TAGGGTTAG-3\' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3\'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.

Aliases: DKFZP586D211 antibody, hPot 1 antibody, hPot1 antibody, POT 1 antibody, POT1 antibody, POT1 like telomere end-binding protein antibody, POT1 protection of telomeres 1 homolog antibody, POT1-like telomere end-binding protein antibody, POTE1_HUMAN antibody, Protection of telomeres 1 antibody, Protection of telomeres 1 homolog (S. pombe) antibody, Protection of telomeres protein 1 antibody

UniProt: Q9NUX5

Pathways: Cycle Cellulaire, Telomere Maintenance