AATF anticorps (AA 6-294)
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- Antigène Voir toutes AATF Anticorps
- AATF (Apoptosis Antagonizing Transcription Factor (AATF))
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Épitope
- AA 6-294
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp AATF est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC)
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human Protein AATF protein (6-294AA)
- Isotype
- IgG
- Top Product
- Discover our top product AATF Anticorps primaire
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- Indications d'application
- Recommended dilution: IHC:1:200-1:500,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- AATF (Apoptosis Antagonizing Transcription Factor (AATF))
- Autre désignation
- AATF (AATF Produits)
- Synonymes
- anticorps AATF, anticorps ded, anticorps che1, anticorps che-1, anticorps cb109, anticorps sb:cb109, anticorps wu:fc13d05, anticorps zgc:162071, anticorps CHE-1, anticorps CHE1, anticorps DED, anticorps 4933415H02Rik, anticorps 5830465M17Rik, anticorps Che-1, anticorps Trb, anticorps Ded, anticorps apoptosis antagonizing transcription factor, anticorps Apoptosis antagonizing transcription factor, anticorps apoptosis antagonizing transcription factor S homeolog, anticorps AATF, anticorps aatf, anticorps BFR2, anticorps NAEGRDRAFT_56916, anticorps Aatf, anticorps aatf.S
- Sujet
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Background: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Aliases: AATF antibody, AATF_HUMAN antibody, Apoptosis antagonizing transcription factor antibody, Apoptosis-antagonizing transcription factor antibody, BFR2 antibody, CHE 1 antibody, CHE1 antibody, DED antibody, Protein AATF antibody, Rb binding protein Che 1 antibody, Rb-binding protein Che-1 antibody
- UniProt
- Q9NY61
- Pathways
- Neurotrophin Signaling Pathway, SARS-CoV-2 Protein Interactome
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