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SAV1 anticorps (AA 1-210)

SAV1 Reactivité: Humain WB, ELISA, IHC, IF, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7166096
  • Antigène Voir toutes SAV1 Anticorps
    SAV1 (Salvador Homolog 1 (SAV1))
    Épitope
    • 8
    • 8
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-210
    Reactivité
    • 29
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 23
    • 6
    • 1
    Lapin
    Clonalité
    • 27
    • 3
    Polyclonal
    Conjugué
    • 20
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp SAV1 est non-conjugé
    Application
    • 27
    • 18
    • 6
    • 4
    • 3
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
     Réactivité croisée
    Humain, Souris
    Purification
    Antigen Affinity Purified
    Immunogène
    Recombinant Human Protein salvador homolog 1 protein (1-210AA)
    Isotype
    IgG
    Top Product
    Discover our top product SAV1 Anticorps primaire
  • Indications d'application
    Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200, IP:1:200-1:2000,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    SAV1 (Salvador Homolog 1 (SAV1))
    Autre désignation
    SAV1 (SAV1 Produits)
    Synonymes
    anticorps SAV, anticorps WW45, anticorps WWP4, anticorps 1700040G09Rik, anticorps Salv, anticorps Sav, anticorps Wwp3, anticorps Wwp4, anticorps salvador family WW domain containing protein 1, anticorps salvador family WW domain containing 1, anticorps SAV1, anticorps Sav1
    Sujet

    Background: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.

    Aliases: 1700040G09Rik antibody, 45 kDa WW domain protein antibody, hWW 45 antibody, hWW45 antibody, Protein salvador homolog 1 antibody, salvador family WW domain containing protein 1 antibody, salvador homolog 1 (Drosophila) antibody, Salvador homolog 1 antibody, Salvador, Drosophila, homolog of antibody, SAV 1 antibody, SAV antibody, SAV1 antibody, SAV1_HUMAN antibody, WW 45 antibody, WW domain containing antibody, WW domain-containing adaptor 45 antibody, WW domain-containing protein, 45-KD antibody, WW45 antibody, WW45 protein antibody, WWP 4 antibody, WWP4 antibody

    UniProt
    Q9H4B6
    Pathways
    Stem Cell Maintenance
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