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SET/TAF-I anticorps (AA 147-235)

SET Reactivité: Humain WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7166106
  • Antigène Voir toutes SET/TAF-I (SET) Anticorps
    SET/TAF-I (SET) (SET Nuclear Oncogene (SET))
    Épitope
    • 12
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 147-235
    Reactivité
    • 75
    • 38
    • 37
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 70
    • 3
    • 2
    Lapin
    Clonalité
    • 62
    • 12
    Polyclonal
    Conjugué
    • 34
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SET/TAF-I est non-conjugé
    Application
    • 52
    • 26
    • 22
    • 13
    • 13
    • 9
    • 7
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Protein SET protein (147-235AA)
    Isotype
    IgG
    Top Product
    Discover our top product SET Anticorps primaire
  • Indications d'application
    Recommended dilution: WB:1:500-1:5000,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    SET/TAF-I (SET) (SET Nuclear Oncogene (SET))
    Autre désignation
    SET (SET Produits)
    Synonymes
    anticorps 2PP2A, anticorps I2PP2A, anticorps IGAAD, anticorps IPP2A2, anticorps PHAPII, anticorps TAF-I, anticorps TAF-IBETA, anticorps 2610030F17Rik, anticorps 5730420M11Rik, anticorps AA407739, anticorps I-2PP2A, anticorps StF-IT-1, anticorps 2pp2a, anticorps i2pp2a, anticorps igaad, anticorps ipp2a2, anticorps phapii, anticorps set, anticorps set-a, anticorps set-b, anticorps taf-ibeta, anticorps wu:fb30g11, anticorps wu:fd16c08, anticorps SET nuclear proto-oncogene, anticorps SET nuclear oncogene, anticorps SET translocation, anticorps SET nuclear proto-oncogene L homeolog, anticorps SET nuclear proto-oncogene b, anticorps SET, anticorps Set, anticorps LOC403555, anticorps set.L, anticorps setb
    Sujet

    Background: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins, however, isoform 2 specific activity is higher.

    Aliases: 2PP2A antibody, HLA DR associated protein II antibody, HLA-DR-associated protein II antibody, I 2PP2A antibody, I-2PP2A antibody, I2PP2A antibody, IGAAD antibody, Inhibitor of granzyme A activated DNase antibody, Inhibitor of granzyme A-activated DNase antibody, Inhibitor of GzmA-activated DNase antibody, inhibitor-2 of protein phosphatase-2A antibody, IPP2A2 antibody, PHAPII antibody, Phosphatase 2A inhibitor I2PP2A antibody, protein phosphatase type 2A inhibitor antibody, Protein SET antibody, Set antibody, SET nuclear oncogene antibody, SET translocation antibody, SET translocation (myeloid leukemia-associated) antibody, SET_HUMAN antibody, TAF I antibody, TAF IBETA antibody, TAF-I antibody, TAFI antibody, Template activating factor I antibody, Template-activating factor I antibody, Template-Activating Factor-I, chromatin remodelling factor antibody

    UniProt
    Q01105
    Pathways
    Apoptose
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