TIMELESS anticorps (AA 1004-1131)

N° du produit ABIN7166187

Détail du produit anti-TIMELESS anticorps

Antigène: TIMELESS (Timeless Homolog (TIMELESS))

Épitope: AA 1004-1131

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TIMELESS est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Protein timeless homolog protein (1004-1131AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:200-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TIMELESS

Antigène: TIMELESS (Timeless Homolog (TIMELESS))

Autre désignation: TIMELESS (TIMELESS Produits)

Synonymes: anticorps TIM, anticorps TIM1, anticorps hTIM, anticorps C77407, anticorps Debt69, anticorps tim, anticorps CG3234, anticorps Dmel\\CG3234, anticorps Ritsu, anticorps Tim, anticorps dTIM, anticorps dTim, anticorps dtim, anticorps mel_tim, anticorps rit, anticorps tim1, anticorps XTimeless1, anticorps timeless, anticorps timelessb, anticorps TIMELESS, anticorps MXC20.14, anticorps MXC20_14, anticorps htim, anticorps im:6903167, anticorps wu:fa95g04, anticorps wu:fd23d07, anticorps timeless circadian regulator, anticorps timeless circadian clock 1, anticorps timeless, anticorps timeless circadian clock, anticorps timeless circadian clock S homeolog, anticorps timeless family protein, anticorps TIMELESS, anticorps Timeless, anticorps tim, anticorps timeless.S, anticorps Tim, anticorps ATIM, anticorps timeless, anticorps LOC100328917

Sujet:

Background: Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.

Aliases: FLJ12640 antibody, FLJ20714 antibody, hTIM antibody, Protein timeless homolog antibody, TIM antibody, TIM_HUMAN antibody, TIM1 antibody, Timeless antibody, timeless circadian clock 1 antibody, timeless circadian clock antibody, timeless homolog antibody, TIMELESS1 antibody, Tof1 homolog antibody

UniProt: Q9UNS1

Pathways: Protein targeting to Nucleus, Photoperiodism