AKT3 anticorps (AA 1-164)

N° du produit ABIN7167032

Détail du produit anti-AKT3 anticorps

Antigène: AKT3 (V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3))

Épitope: AA 1-164

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AKT3 est non-conjugé

Application: ELISA, Immunoprecipitation (IP)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human RAC-gamma serine/threonine-protein kinase protein (1-164AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IP:1:200-1:2000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur AKT3

Antigène: AKT3 (V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3))

Autre désignation: AKT3 (AKT3 Produits)

Synonymes: anticorps MPPH, anticorps PKB-GAMMA, anticorps PKBG, anticorps PRKBG, anticorps RAC-PK-gamma, anticorps RAC-gamma, anticorps STK-2, anticorps AI851531, anticorps D930002M15Rik, anticorps Nmf350, anticorps Pkbg, anticorps AKT serine/threonine kinase 3, anticorps thymoma viral proto-oncogene 3, anticorps v-akt murine thymoma viral oncogene homolog 3b, anticorps AKT3, anticorps Akt3, anticorps akt3b

Sujet:

Background: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.

Aliases: Akt3 antibody, AKT3 kinase antibody, AKT3_HUMAN antibody, DKFZp434N0250 antibody, MPPH antibody, PKB gamma antibody, PKBG antibody, PRKBG antibody, Protein kinase Akt-3 antibody, Protein Kinase AKT3 antibody, Protein kinase B gamma antibody, RAC gamma antibody, RAC gamma serine/threonine protein kinase antibody, RAC-gamma serine/threonine-protein kinase antibody, RAC-PK-gamma antibody, RACPK Gamma antibody, Serine threonine protein kinase Akt 3 antibody, Serine threonine protein kinase Akt3 antibody, STK 2 antibody, STK-2 antibody, STK2 antibody, V akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) antibody, V akt murine thymoma viral oncogene homolog 3 antibody, V akt murine thymoma viral oncogene homolog 3 protein kinase B gamma antibody

UniProt: Q9Y243

Pathways: Signalisation PI3K-Akt, Signalisation RTK, Signalisation TLR, Hepatitis C, VEGF Signaling